Publications & Awards

Kezirian, E., Goding, G. S., Malhotra, A., O’Donoghue, F. J., Zammit, G.  et. al.  (2014).  Hypoglossal nerve stimulation improves obstructive sleep apnea: 12-month outcomes.  Journal of Sleep Research, 23, 77 – 83.

Huang DB, Pastagia M, Chiang, T. Challenges to conducting a clinical trial of combination therapy of colistin and rifampicin for extensively drug-resistant Acinetobacter baumannii. Clinical Infectious Diseases. 2014 Jan;58(1):141-2.
 
Pastagia M, Jenkins SG. Salmonella neck abscess as an opportunistic infection in diabetes mellitus. Case Reports Infectious Diseases. 2013; vol 2013.
 
Pastagia M, Schuch R, Fischetti VA, Huang, DB. Lysins: The arrival of pathogen-directed anti-infectives. Journal of Medical Microbiology. 2013 Oct; 62:1506-16.

Rice, T. B., Foster, G. D., Sanders, M. H., Unruh, M., Reboussin, D., Kuna, S., Millman, R., Zammit, G., Wing, R., Wadden, T. A., Kelley, D., Pi-Sunyer, X., & Newman, A. B., (2012).  The relationship between obstructive sleep apnea and self-reported stroke or coronary disease in overweight and obese adults with type 2 diabetes mellitus.  Sleep, 35, 1293 – 1298.

Pastagia M, Kleinman LC, Lacerda EG, Jenkins SG. Predicting risk for death from MRSA bacteremia. Emerging Infectious Diseases. 2012; 18(7): 1072-80.
 
St-Onge, M. P., Zammit, G., Reboussin, D. M., Kuna, S., Sanders, M., Millman, R., Newman, A., Wadden, T. A., Wing, R. R., Pi-Sunyer, F. X. & Foster, G.  (2012).  Associations of sleep disturbance and duration with metabolic risk factors in obese persons with type 2 diabetes: data from the sleep AHEAD study.  Nature and Science of Sleep, 4, 143 – 150.
 
Shechter, A., O’Keeffe, M., Roberts, A. L., Zammit, G. K. et. al.  (2012).  Alterations in sleep architecture in response to experimental sleep curtailment are associated with signs of positive energy balance.  Am. J. Physiol. Regul. Integr. Comp. Physiol., 303, R883 – 889.
 
Greenblatt, D. & Zammit, G.  (2012).  Pharmacokinetic evaluation of eszopiclone: clinical and therapeutic implications.  Expert Opinion on Drug Metabolism and Toxicology, 8, 1609 – 1618.

A. Malhotra, P. Eastwood, D. Hillman, E.J. Kezirian, R.D. McEvoy, J. Wheatley, F. O'Donoghue, P. Catcheside, N.A. Antic, C. Worsnop, M. Campbell, G. Hee, C. Palme, C. Iber, M. Howell, G. Goding, Jr., G. Zammit, S. Park, D. Claman, T. Huntley, P.L. Smith, A.R. Schwartz, M. Barnes. Hypoglossal Nerve Stimulation Therapy To Treat Obstructive Sleep Apnea: Long-Term Effectiveness Outcomes. (2012). Am J Respir Crit Care Med 185;A3849.

Pastagia M, Euler C, Chahales P, Fuentes-Duculan J, Krueger J, Fischetti V. A novel chimeric lysin shows superiority to mupirocin for skin decolonization of antibiotic resistant (MRSA) and sensitive (MSSA) Staphylococcus aureus. Antimicrobial Agents and Chemotherapy. 2011; 55(2): 738-44.

Krystal, A. D.; Zammit, G. K.; Wyatt, J. K.; Quan, S. F.; Edinger, J. D.; White, D. P.; & Malholtra, A.  (2010).  The Effect of Vestibular Stimulation in a Four-Hour Sleep Shase Advance Model of Transient Insomnia.  Journal of Clinical Sleep Medicine, 6, 315 – 321.

Thomas Roth, PhD; Gary Zammit, PhD; Alan Lankford, PhD; David Mayleben, PhD; Theresa Stern, PhD; Verne Pitman, PharmD; David Clark, MRCP; John L. Werth, PhD. Nonrestorative Sleep as a Distinct Component of Insomnia. SLEEP, Vol. 33, No. 4, 2010.

Gary K. Zammit, PhD; Norman M. Goldfarb. Expanding a Site into Phase I Trials. Journal of Clinical Research Best Practices Vol. 6, No. 6, June 2010. 

Pastagia M, Caplivski D. Disseminated cryptococcosis resulting in miscarriage in a woman without other immunocompromise: a case report. International Journal of Infectious Dis. 2010; 14(5): 441-3.

James E. Gangwisch, PhD; Lindsay A. Babiss, BA; Dolores Malaspina, M3; J. Blake Turner, PhD; Gary K. Zammit, PhD; Kelly Posner, PhD. Parental Set Bedtimes and Risk for Depression — Earlier Parental Set Bedtimes as a Protective Factor Against Depression and Suicidal Ideation. SLEEP, Vol. 33, No. 1, 2010.

Foster, G; Borradaile, K; Sanders, M; Millman, R; Zammit, G; Newman, A; Wadden, T; Kelley, D; Wing, R; Pi-Sunye, F X; Reboussin, D; Kuna, S. A Randomized Study on the Effect of Weight Loss on Obstructive Sleep Apnea Among Obese Patients With Type 2 Diabetes. ARCH INTERN MED/VOL 169 (NO. 17), Sept 2009.

Lee J, Pastagia M. Peritoneal tuberculosis. International Journal of Infectious Dis. 2009; 13(1): 117.

August 2009: Voted One of Inc. Magazine's Fastest Growing Companies

Zammit G. K. Comparative Tolerability of Newer Agents for Insomnia. Drug Safety 2009; 32 (9). 

Balkrishnan, R., Joish, V. N., Koerber, C., Rosekind, M., Lerner, D., Kong, M., & Zammit, G. (2009). Impact of Nighttime Awakenings on Worker Productivity and Performance. Sleep, 32, Abstract Supplement, A257.

Moore, P., Zammit, G., Yen, M., Lankford, A., Scharf, M., Rosenberg, R., Edinger, J., & Krystal, A. (2009). The Influence of Morningness-Eveningness on Latency to Persistent Sleep in a Model of Transient Insomnia. Sleep, 32, Abstract Supplement, A60.

Kuna, S. t., Borradiale, K. E., Sanders, M. H., Millman, R. P., Zammit, G. K., Wadden, T. A., Kelley, D. E., Wing, R. R., Pi-Sunyer, F. X., & Foster, G. (2009). Symptom Questionnaires Do Not Predict the Presence or Severity of Obstructive Sleep Apnea in Obese Patients with Type 2 Diabetes. Sleep, 32, Abstract Supplement, A170.

Quan, S., Zammit, G., Malhotra, A., Wyatt, J., Edinger, J., & Krystal, A. (2009). The Relationship Between MSLT Nap Onset Latency and the Effect of Vestibular Stimulation on Transient Insomnia. Sleep, 32, Abstract Supplement, A288.

Zammit, G., Lankford, A., Rosenberg, R., Scharf, M., Moore, P., Yen, M., Edinger, J., & Krystal, A. (2009). The Effect of Vestibular Stimulation on Transient Insomnia Induced by a Five-Hour Phase Advance. Sleep, 32, Abstract Supplement, A289.

Taub, L.F., Lund S., Freeman, J., Anwar, S., Segal, O. Differences in Sleep Quality and Daytime Sleepiness Before and After CPAP Use – accepted for publication in Sleep, 2009, presented at the AASM meeting, Seattle, June, 2009.

Khan, Z., Hyatt, S., Bachan, M., Jones, D., Ghassibi, J., Lund, S., Freeman, J.Oxygen saturation in obstructive sleep apnea (OSA) and normal controls: Comparison between REM versus NREM and phasic REM (PREM) versus tonic REM (TREM) – accepted for publication in Sleep, 2009 and presented at the AASM meeting, Seattle, June, 2009.

Lund, S. and Freeman, J. Polysomnography. In: Sleep Apnea and Snoring – Surgical and Non-Surgical Therapy, Friedman, M. (ed.). Saunders/Elsevier, 2009, 22 – 32.

Taub, L.F., Lund S., Freeman, J., Anwar, S., Segal, O. Differences in Sleep Quality and Daytime Sleepiness Before and After CPAP Use – accepted for publication in Sleep, 2009 and to be presented at the AASM meeting, Seattle, June, 2009.

Khan, Z., Hyatt, S., Bachan, M., Jones, D., Ghassibi, J., Lund, S., Freeman, J.Oxygen saturation in obstructive sleep apnea (OSA) and normal controls: Comparison between REM versus NREM and phasic REM (PREM) versus tonic REM (TREM) – accepted for publication in Sleep, 2009 and to be presented at the AASM meeting, Seattle, June, 2009.

August 2008: Voted One of Inc. Magazine's Fastest Growing Companies

Zammit G.K., Schwartz H., Roth T., Wang-Weigand S., Sainati S., Zhang J. The effects of ramelteon in a first-night model of transient insomnia. Sleep Med. Aug. 2008.

Pastagia M, Arumugam V. Klebsiella liver abscess in a public hospital in New York.  Travel Medicine and Infectious Disease. 2008; 6(4): 228-33.
 
Pastagia M, Caplivski D. Sexually Transmitted Diseases. Book chapter in:  HIV and comorbidities: a case based approach to diagnosis and management. Oxford University Press. 2008.

Gangwisch J.E., Heymsfield S.B., Boden-Albala B., Buijs R.M., Kreier F., Opler M.G., Pickering T.G., DPhil; Rundle A.G., Zammit G.K., Malaspina D. Sleep Duration Associated with Mortality in Elderly, but not Middle-Aged, Adults in a Large US Sample. SLEEP. Vol. 31, No. 8: 1087-1096. Aug. 2008.

Zammit G.K., Wang-Weigand S., Peng X. Use pf computerized dynamic posturography to assess balance in older adults after night time awakenings using zolpidem as a reference. BMC Geriatrics 8:15. July 15 2008.

Erman M.K, Zammit G.K., Rubens R, Schaefer K, Wessel T, Amato D, Caron J, Walsh J.K. A polysomnographic placebo-controlled evaluation of the efficacy and safety of eszopiclone relative to placebo and zolpidem in the treatment of primary insomnia. J Clin Sleep Med. 2008 Jun 15;4(3):229-34.

Zammit G.K. Antidepressants and Insomnia. Primary Psychiatry. Vol 15, No.5: 61-69. 2008.

Zammit G.K. Zolpidem Extended-Release: Therapy for Sleep Induction and Sleep Maintenance Difficulties. Expert Opin. Drug Metab. Toxicol. Vol 4, No.3: 325-331. 2008.

Zammit, G. K., Accomando, W., Sprenger, K., & Aneiro, L. (2008). Rapid sleep onset in patients with chronic insomnia with no tolerance or rebound insomnia after 14 days of treatment with adipiplon. Sleep, 31, Abstract Supplement, A245.

Zammit, G. K. Ding, Y., & McCoy, A. (2008). The use of a virtual private network (VPN) to manage global clinical trials: analysis of cost and performance. Presented at the annual meeting of the Drug Information Association, June 24, Boston, MA.

Coelho-D’Costa, V., Tsegaye, A., Freeman, J., Lund, S. PAP (Positive Airway Pressure) titration via split-night polysomnography (SNP) vs full night PAP titration (FNT) in pts with OSA – accepted for publication in Sleep, 2008, 31, A0469 and presented at the AASM meeting, Baltimore, Maryland, June, 2008.

Yadgarov, D., Liang, L., Freeman, J., Lund, S. Using Cyclic Alternating Pattern as a predictor of an optimal CPAP titration – accepted for publication in Sleep, 2008, 31, A0491 and presented at the AASM meeting, Baltimore, Maryland, June, 2008.

Zammit G.K. Ramelteon: A Novel Hypnotic Indicated for the Treatment of Insomnia. Psychiatry. Vol 4, No. 9. 36-42. September 2007

Zammit G.K. Balance Assessment After Nighttime Awakenings in Healthy Older Adults With and Without Zolpidem Administration. Presented at Society For Neuroscience, 37th Annual Meeting. November 2007

Zammit G.K. The Prevalence, Morbidities, and Treatments of Insomnia. Neurological Disorders: Drug Targets. Vol. 6: 3-16.

Erman M, Krystal A, Zammit G.K., Soubrane C, Roth T. Long-term Efficacy of Zolpidem Extended-Release in the Treatment of Sleep Maintenance and Sleep Onset Insomnia with Improvements in Next-Day Functioning. SLEEP. Vol. 30, Abstract Suppl: A241.

Gangwisch JE, Heymsfield SB, Boden-Albala B, Buijs RM, Kreier F, Pickering TG, Rundle AG, Zammit G.K., Malaspina D. Sleep Duration as a Risk Factor for Diabetes Incidence in a Large US Sample. SLEEP. Vol. 20, No. 12.

Zammit, G. K. 2007). The prevalence, morbidities, and treatments of insomnia.  CNS Neurological Disorders: Drug Targets, 6, 3 – 16.

Gangwisch, J. E., Heymsfield, S. B., Boden-Albala, B., Buijs, R. M., Kreier, F., Pickering, T. G., Rundle, A. G., Zammit, G. K., Malaspina, D. (2007).  Sleep duration as a risk factor for diabetes incidence in a large US sample, Sleep, 30, 1667 – 1673.

Zammit, G. K.  (2007).  Ramelteon: A novel hypnotic indicated for the treatment of insomnia.  Psychiatry, 4, 36 – 42.

Roth T., Zammit G.K., Scharf M., Farber R.  (2007).  Efficacy and Safety of As-Needed, Post Bedtime Dosing with Indiplon in Insomnia Patients with Chronic Difficulty Maintaining Sleep.  Sleep; 30(12):1731-1738.

Gangwisch, J. E., Heymsfied, S. B., Boden-Albala, B., Buijs, R. M., Kreier, F., Pckering, T. G., Rundle, A. G., Zammit, G. K., Malaspina, D.  (in preparation).  Sleep duration associated with mortality in elderly, but not middle-aged adults in a large U.S. sample” or “Age differences in the association between sleep duration and mortality in a large U.S. sample.

Najib, J. & Zammit, G. K. (in preparation).  Eszopiclone: Efficacy and Safety.  In Pandi-Perumal, Verster, Monti, Lader, & Langer (Eds.), Sleep Disorders: Diagnosis and Therapeutics. 

Greenblatt, D., Harmatz, J., Zammit, G.K., Accomando, W., Sprenger, K., & Aneiro, L.  (2007).  Pharmacokinetic-Pharmacodynamic Effects of NG2-73, A Novel GABA(A) Agonist and Zolpidem.  Sleep, 30, Abstract Supplement, A40.

Zammit, G., Rice, K., Accomando, W., Sprenger, K., & Aneiro, L.  (2007). Effects of NG2-73 on Sleep Onset, Quality and Next Day Function in a Transient Insomnia Study.  Sleep, 30, Abstract Supplement, A239.

Erman, M., Krystal, A., Zammit, G., Soubrane, C., & Roth, T.  (2007).  Long-term efficacy of zolpidem extended-release in the treatment of sleep maintenance and sleep onset insomnia with improvements in next-day functioning.  Sleep, 30, Abstract Supplement, A241.

Erman, M., Krystal, A., Zammit, G., Soubrane, C., & Roth, T.  (2007).  No evidence of rebound insomnia in patients with chronic insomnia treated with zolpidem extended-release 12.5 mg administered “as needed” 3 – 7 nights/week for 6 months.  Sleep, 30, Abstract Supplement, A241.

Wang-Weigand, S., Zammit, G., & Peng, X.  (2007).  Effect of Ramelteon on middle-of-the-night balance, mobility, and memory performance in older adults.  Sleep, 30, Abstract Supplement, A244.

Ahmad, M. Caffrey, P., Freeman, J., Lund, S. Rapid Eye Movement (REM) Density and Eye Movement Distribution in Patients Taking Selective Serotonin Reuptake Inhibitors (SSRI) – Sleep, 2007, 30, A337 and presented at the AASM meeting, Minneapolis, Minnesota, June, 2007.

Bhola, A., Mouskourie, E., Freeman, J., Lund, S. Gender and age differences in the initial acceptability of continuous positive airway pressure (CPAP) in obstructive sleep apnea – Sleep, 2007, 30, A200 and presented at the AASM meeting, Minneapolis, Minnesota, June, 2007.

Verma, N., Konstantinova, N., Freeman, J., Lund, S. Comparison of subjective and objective assessment of sleep onset (SO) on the multiple sleep latency test (MSLT) using standard and microsleep criteria – Sleep, 2007, 30, A353 and presented at the AASM meeting, Minneapolis, Minnesota, June, 2007.

Oropello, J., Ostrovskaya, M., Freeman, J., Lund, S. Do Mallampati scores correlate with optimal continuous positive airway pressure (CPAP) determined by CPAP titration during full-night polysomnography? – Sleep, 2007, 30, A185 and presented at the AASM meeting, Minneapolis, Minnesota, June, 2007.

Kaul, V., Rampersaud, R., Heddings, L., Freeman, J., Lund, S. Affective and Cognitive symptoms in NREM versus REM obstructive sleep apnea – presented at the North East Sleep Society, 21st Annual Meeting, March, 2007 

2006
Erman M, Seiden D, Zammit G.K., Sainati S, Zhang J. An Efficacy, Safety, and Dose-Response Study of Ramelteon in Patients with Chronic Primary Insomnia. Sleep Medicine. Vol. 7: 17-24.

Walsh JK, Zammit G.K., Schweitzer PK, Ondrasik J, Roth T. Tiagabine Enhances Slow Wave Sleep and Sleep Maintenance in Primary Insomnia. Sleep Medicine. Vol. 7: 155-161.

Zammit G.K. HD-16: Measuring Quality of Life in Insomnia. Insom. Vol. 7: 33-35.

Ghassibi J, Freeman JZammit G.K., Ghassibi M. Correlation Between Daytime Functioning Score and Severity of Obstructive Sleep Apnea (OSA). SLEEP. Vol. 29, Asbtract: A157.

Zammit G.K., Schwartz H, Roth T, Wang-Weigand S, Zhang J. Effect of Ramelteon, a Selective MT1/MT2 Receptor Agonist, in a First-Night-Effect Model of Transient Insomnia. SLEEP. Vol. 29, Asbtract: A238.

Greenblatt D, Legangneux E, Harmatz J, Weinling E, Freeman J, Rice K,Zammit G. Dynamics and Kinetics of a Modified-Release Formulation of Zolpidem: Comparison With Immediate-Release Standard Zolpidem and Placebo. Journal of Clinical Pharmacology 2006;46:1469-1480.

Malli, D., Adachi, M., Ghassibi, J., V., Freeman, J., Lund, S. Correlation between body mass index, apnea/hypopnea index and CPAP pressure requirements in patients with obstructive sleep apnea – presented at the North East Sleep Society, 20th Annual Meeting, March 17, 2006.

Coelho-D’Costa, V., Tsegaye, A. Freeman, J., Lund, S. Comparison of positive airway pressure (PAP) titration via split-night study polysomnography vs full night PAP titration in patients with obstructive sleep apnea - presented at the North East Sleep Society, 20th Annual Meeting, March 17, 2006.

Damian, J., Coelho-D’Costa, V., Narasimhan, M., Freeman, J., Lund, S.Referral patterns from various types of subspecialists to a sleep center & their accuracy in predicting the diagnosis of obstructive sleep apnea” – presented at the North East Sleep Society, 20th Annual Meeting, March 17, 2006.

Zammit, G. K. Gold Standard Celebrates Silver Anniversary. Advance for Managers of Respiratory Care. 39-41. November 2006.

McCall WV, Erman M, Krystal AD., Rosenberg R., Scharf M., Zammit, GK., Wessel T. A polysomnography study of eszopiclone in elderly patients with insomnia. Current Medical Research and Opinion, Vol. 22, No. 9, 2006, 1633-1642.

Zammit, G. K., Corser, B., Doghramji, K., Fry , J. M. , Krystal , A., James , S., & Mangano, R. M. (2006). Sleep and Residual Sedation After Administration of Zaleplon, Zolpidem, and Placebo During Experimental Middle-of-the-Night Awakening. Journal of Clinical Sleep Medicine, 2006 Nov 4. Vol. 2. 417-423.

Zammit, G. K. (2006). Indiplon: A single compound in two formulations for the treatment of insomnia. Future Neurology, 1, 259 – 268.

Gangswisch, J. E. , Heymsfield, S. B. , Boden-Albala, B., Buijs, R. M., Kreier, F., Pickering, T. G., Rundle, A. G., Zammit, G. K., Malaspina, D. (2006). Short sleep duration as a risk factor for hypertension. Analysis of the First National Health and Nutrition Examination Survey. Hypertension, 47, 833 - 839.