Phase 1 Clinical Trials
Early-phase CNS studies are unique; very different from trials in other indications that don’t involve the brain. Drug developers working in psychiatric and neurological indications must document CNS activity, safety, pharmacokinetics, and pharmacodynamics. It takes a company with expertise to deliver the early-phase data that launch an investigational new drug into late phase clinical development.
The best way to predict the future is to invent it.
The greatest joy in life is to accomplish. It is the getting, not the having. It is the giving, not the keeping.
Without drugs, physicians would struggle to find relevance, and patients would suffer without hope.
I trust I may be enabled in the treatment of patients always to act with a single eye to their good.
It is easy to get a thousand prescriptions, but hard to get one single remedy.
One sometimes finds what one is not looking for.
The cures we want aren’t going to fall from the sky. We have to get ladders and climb up and get them.
Good information is the best medicine.
I am not accustomed to saying anything with certainty after only one or two observations.
Drugs don’t work in patients who don’t take them.
The reward for work well done is the opportunity to do more.
All truths are easy to understand once they are discovered; the point is to discover them.
I must say, I spend a lot of my time these days trying to persuade people that controlled trials are the only way to get information that’s reliable about drugs.
I have no ideology. My ideology is health.
Let me tell you the secret that has led me to my goal. My strength lies solely in my tenacity.
If you think compliance is expensive, try non-compliance.
One never notices what has been done; one can only see what remains to be done.
Advances in drug development have led to greater improvement in the quality of human life than advances in all other fields combined.
Remember the Three Princes of Serendip who went out looking for treasure? They didn’t find what they were looking for, but they kept finding things just as valuable. That’s serendipity, and our business [drugs] is full of it.
The pace of discovery is going unbelievably fast.
There is so much more to be done; the patients are waiting.